In the last two decades, numerous studies have shown that both Aβ and tau proteins adopt pathogenic, self-propagating conformations characteristic of prions (21–26).Prions induce the misfolding of additional copies of the naïve protein (e.g., Aβ or tau) in a self-perpetuating process that spreads within and between neural cells (what we …
Results: Bone mineral density improved in spine, hips, and femur of the 227 moderately and fully compliant patients. Monthly gain in BMD was significant in spine (0.0029 g/cm 2, P = .005) and femur (0.00022 g/cm 2, P = .053), but in 1 cohort, although mean gain in hip BMD was 50%, large individual differences raised the confidence …
Acute Study—exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: –3.44 ± 2.63% versus 1.44 ± 4.18% area lipid staining, P < 0.01) and type II fibers (–1.89 ± 2.48% versus 1.83 ± 1.92% area lipid staining, P < 0.05). Training Study—postprandial glycemia was not differentially affected …
These journals published a total of 4,986,335 articles of which 4,183,917 were considered research articles (i.e., original articles, case reports, and reviews; S1 Fig).The main characteristics of the journals analyzed are described in Table 1.Briefly, they published a median of 500 articles (IQR 262 to 964) for the 2015 to 2019 period, of which …
Previous studies have suggested that Venus may have been a much more hospitable place in the past, with its own liquid water oceans. A team of astrophysicists led by the University of Geneva (UNIGE) and the National Centre of Competence in Research (NCCR) PlanetS, Switzerland, investigated whether our planet's twin did indeed have …
Obesity is linked with the brain aging faster than would normally be expected. Researchers are able to capture this process by calculating a person's 'brain age' – how old their brain appears on detailed scans, regardless of chronological age. This approach also helps to monitor how certain factors, such as lifestyle, can influence brain aging over …
Discussion. In this multistate analysis of 85,075 hospitalizations of persons with COVID-19–like illness, bivalent doses were 62% effective among adults without immunocompromising conditions, and 28% effective in those with immunocompromising conditions in preventing COVID-19–associated hospitalization during the first 7–59 days …
Neutering (including spaying) of male and dogs in the first year after birth has become routine in the U.S. and much of Europe, but recent research reveals that for some dog breeds, neutering may be associated with increased risks of debilitating joint disorders and some cancers, complicating pet owners' decisions on neutering. The joint disorders …
How do people believe they can best maintain sexual satisfaction in their romantic relationships? In the current research, we draw upon the literature on implicit theories of relationships to develop and validate a scale examining 2 types of lay beliefs about how sexual satisfaction can be maintaine …